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合成了三种新的配合物[Cu(TATP)(L-Val)(H2O)]ClO4.0.5H2O(1)、[Cu(TATP)(L-Ser)(H2O)]ClO4(2)、[Cu(TATP)(L-Arg)(H2O)]2ClO4.0.5H2O(3)(TATP=1,4,8,9-四氮三联苯,L-Val=L-缬氨酸,L-Ser=L-丝氨酸,L-Arg=L-精氨酸),并通过元素分析、红外光谱、紫外-可见光谱和摩尔电导率对其进行了表征。此外,用改进的氮蓝四唑(NBT)光还原法测定了上述配合物以及配合物[Cu(TATP)(L-Tyr)(H2O)]ClO4.H2O(4)(L-Tyr=L-酪氨酸)对O2-.歧化的催化作用。结果表明,配合物均具有良好的超氧化歧化酶(SOD)活性,在0.2～0.9μmol.L-1浓度范围内抑制率达到50%以上,活性大小按1>3>2>4排列。
Three novel complexes [Cu (TATP) (L-Val) (H2O)] ClO4.0.5H2O (1), [Cu (TATP) (L-Ser) Cu (TATP) (L-Arg) (H2O)] 2ClO4.0.5H2O (3) (TATP = 1,4,8,9-tetraazatrienediphenyl, L- Val = L-Valine, L-Ser = L-serine, L-Arg = L-arginine) were synthesized and characterized by elemental analysis, IR, UV-Vis and molar conductivity. In addition, the above complexes and complexes [Cu (TATP) (L-Tyr) (H2O)] ClO4.H2O (4) (L-Tyr = L- Tyrosine) on the O2-. Disproportionation of the catalytic effect. The results showed that all the complexes had good activity of superoxide dismutase (SOD). The inhibitory rate reached more than 50% in the concentration range of 0.2 ~ 0.9μmol.L-1, and the activity size was arranged according to 1> 3> 2> 4.