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目的在新生儿惊厥中尽管给予多种抗癫痫药物治疗,但仍不能完全控制。方法讨论新生儿惊厥中抗癫痫药物的选择、癫痫控制、抗癫痫药物的数量与预后之间的关系。研究方法:我们纳入了88名新生儿惊厥的患儿(生于1998年至2006年),其中难治性癫痫为46人,预后正常的35人,预后异常的11人;一般癫痫42人,其中预后正常的33人,异常的9人。分析抗癫痫药物选择、抗癫痫药物的数量和的关系。儿童预后分为正常(临床和脑电均无发作)和异常(包括脑瘫、癫痫、发育落后和死亡)。结果在新生儿惊厥中首选的抗癫痫药物为苯巴比妥钠,其次是其次为妥泰、咪唑安定;结论 1种抗癫痫药物能控制的惊厥预后较好,需要2种以上抗癫痫药物治疗的惊厥中,预后和癫痫能否控制相关,而需要应用的抗癫痫药物数量和预后之间则没有明确的关联。
Purpose Although neonatal seizures in spite of a variety of antiepileptic drugs, but still can not be completely controlled. Methods To discuss the relationship between antiepileptic drug selection, epilepsy control, number of antiepileptic drugs and prognosis in neonatal seizures. METHODS: We enrolled 88 infants (born between 1998 and 2006) with seizures in newborns, including 46 with refractory epilepsy, 35 with normal prognosis and 11 with abnormal prognosis; 42 with generalized epilepsy, Among them, 33 patients had normal prognosis and 9 were abnormal. Analysis of antiepileptic drug selection, the number of antiepileptic drugs and the relationship. Childhood prognosis is divided into normal (no clinical and EEG episodes) and abnormalities (including cerebral palsy, epilepsy, developmental and death). Results The antiepileptic drugs preferred in neonatal seizures were phenobarbital sodium, followed by topiramate and midazolam. CONCLUSIONS: One antiepileptic drug can control the prognosis of convulsions well and need more than two antiepileptic drugs Of the convulsions, the prognosis and whether the control of epilepsy, and the need to apply antiepileptic drugs between the number and prognosis are not clearly related.