论文部分内容阅读
目的观察氯吡格雷联合阿司匹林治疗老年冠心病患者的临床疗效。方法将老年冠心病患者120例按照随机数字法分为观察组和对照组各60例。对照组给予阿司匹林治疗,观察组在对照组基础上给予氯吡格雷治疗,对比观察2组患者治疗过程中不良反应发生情况及治疗前后血小板聚集率、血清C反应蛋白(CRP)水平变化情况。结果观察组不良反应发生率为8.33%(5/60)低于对照组的18.33%(11/60),差异有统计学意义(χ2=4.3278,P<0.05);治疗前2组血小板聚集率和血清CRP水平比较差异无统计学意义(P>0.05),治疗后2组患者血小板聚集率、血清CRP水平均明显改善,且观察组优于对照组,差异均有统计学意义(P<0.05)。结论氯吡格雷联合阿司匹林治疗冠心病患者,不但能快速帮助患者改善临床症状,且不良反应较少,安全性更高,值得临床推广。
Objective To observe the clinical effect of clopidogrel combined with aspirin in elderly patients with coronary heart disease. Methods A total of 120 elderly patients with coronary heart disease were randomly divided into observation group and control group according to random number method. The control group was given aspirin. The observation group was treated with clopidogrel on the basis of the control group. The incidence of adverse reactions and the platelet aggregation rate and serum C-reactive protein (CRP) level before and after treatment were compared between the two groups. Results The incidence of adverse reactions in the observation group was 8.33% (5/60), which was lower than that in the control group (18.33%, 11/60) (χ2 = 4.3278, P <0.05) (P <0.05). The platelet aggregation rate and serum CRP level in two groups were significantly improved after treatment, and the difference between the two groups was statistically significant (P <0.05) ). Conclusion Clopidogrel combined with aspirin in patients with coronary heart disease, not only can quickly help patients improve clinical symptoms, and fewer adverse reactions, higher safety, worthy of clinical promotion.