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目的探讨多囊卵巢综合征(PCOS)患者视黄醇结合蛋白4(RBP4)水平变化及其临床意义。方法 80例PCOS患者包括IR组43例和非IR组37例,正常对照组30例,检测各组血清RBP4、胰岛素、空腹血糖。采用单因素方差分析和相关分析等进行医学统计分析。结果 PCOS患者RBP4含量均显著高于对照组(P<0.05)。PCOS患者HOMA-IR和RBP4正相关(r=0.534,P<0.01)。结论 RBP4可能是联系PCOS发病机制的一个重要的细胞因子。
Objective To investigate the level of retinol binding protein 4 (RBP4) in patients with polycystic ovary syndrome (PCOS) and its clinical significance. Methods 80 cases of PCOS patients including 43 cases of IR group and 37 cases of non-IR group, 30 cases of normal control group, the detection of serum RBP4, insulin, fasting blood glucose. One-way ANOVA and correlation analysis were used to carry out medical statistical analysis. Results RBP4 levels in PCOS patients were significantly higher than those in control group (P <0.05). There was a positive correlation between HOMA-IR and RBP4 in patients with PCOS (r = 0.534, P <0.01). Conclusion RBP4 may be an important cytokine in the pathogenesis of PCOS.