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近年来,干细胞体内分化的研究得到了广泛的开展,其中干细胞曲细精管内移植与分化的相关研究取得了令人瞩目的进展,常用的曲细精管内移植的方法有曲细精管注射法、睾丸输出管注射法和睾丸网注射法,各有优缺点。所移植的细胞可以为精原干细胞、体外分化的胚胎干细胞和诱导多能性干细胞及成体干细胞,从而为研究睾丸细胞功能、生物学特性及更好地保存个体基因组和治疗某些疾病所引起的少精子症、无精子症提供强而有力的生物学工具。
In recent years, the research on stem cell differentiation in vivo has been widely carried out. Among them, the research on stem cell transplantation and differentiation in the seminiferous tubules has made remarkable progress. The commonly used methods of intradermal spermatic tube transplantation include seminiferous tubule injection , Testicular injection tube injection and testicular injection, each have their own advantages and disadvantages. Transplanted cells can be spermatogonial stem cells, in vitro differentiated embryonic stem cells and induced pluripotent stem cells and adult stem cells, so that in order to study the function of testicular cells, biological characteristics and better preservation of individual genomes and the treatment of certain diseases caused Less sperm disease, azoospermia provide powerful biological tools.