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过去20多年在绝大多数有恶性疟传播的国家,已证实原虫对氯喹产生抗性。随后在许多国家也产生了对替代的抗疟药的抗性。曾经提出了抗疟药抗性发展的许多机制。对于抗氯喹恶性疟(CRPF)的机制包括药压,亚治疗剂量的广泛使用,人口迁移和抗性原虫的毒力增强等。体外试验和各种动物模型的研究表明,在连续或反复的药压下,原虫可降低对药物的敏感性。因此推测滥用药物,
Protozoa have been shown to be resistant to chloroquine in more than two decades in the vast majority of countries where falciparum malaria is transmitted. Subsequent resistance in many countries to alternative antimalarial drugs also occurred. Many mechanisms have been proposed for the development of antimalarial resistance. Mechanisms for resistance to chloroquine falciparum malaria (CRPF) include drug pressure, extensive use of sub-therapeutic doses, population shifts and increased virulence of resistant protozoa. In vitro studies and studies in a variety of animal models have shown that protozoa reduce their susceptibility to drugs under continuous or repeated drug pressure. Therefore speculated that drug abuse,