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肾素—血管紧张素系统(RAS)抑制剂因能控制血压、保护血管及改善心血管病预后成为一项独立治疗。颈动脉内膜中层厚度(IMT)被证实是动脉粥样硬化性疾病的预测因子,同时能预测心血管病的发病和死亡[1]。RAS抑制剂对降低或延缓IMT进展尚存争议。研究证实他汀类药物、维生素、抗高血压药能降低IMT甚至逆转粥样硬化斑块进展,减少心血管病发病率。本文就RAS抑制剂对IMT的影响及研究进展做一综述。
Renin-angiotensin system (RAS) inhibitors become an independent treatment because of their ability to control blood pressure, protect blood vessels and improve the prognosis of cardiovascular disease. Carotid intima-media thickness (IMT) has been shown to be a predictor of atherosclerotic disease and to predict cardiovascular morbidity and mortality [1]. RAS inhibitors reduce or delay the progress of IMT is controversial. Studies confirm that statins, vitamins, antihypertensives can reduce IMT or even reverse the progress of atherosclerotic plaque, reduce the incidence of cardiovascular disease. This article reviews the impact of RAS inhibitors on IMT and its research progress.