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目的 :观察食管癌患者血清一氧化氮 (NO)含量变化及其与肿瘤恶性程度的关系。方法 :应用改进的Griess法测定 2 8例食管癌患者血清NO含量 ,并探讨其与食管癌的病理分级、淋巴结转移的关系。结果 :食管癌患者血清NO含量明显高于对照组 (P <0 .0 1) ;病理分级中 ,ⅡⅢ级组血清NO含量显著高于Ⅰ级组 (P <0 .0 1) ,Ⅲ级组血清NO含量显著高于Ⅱ级组 (P <0 .0 5 ) ;血清NO含量变化与淋巴结转移无关。结论 :测定血清NO含量对食管癌的诊断和预后判断有一定的参考价值
Objective: To observe the changes of serum nitric oxide (NO) in esophageal cancer patients and its relationship with malignancy. METHODS: The serum NO levels in 28 patients with esophageal cancer were measured by modified Griess method. The relationship between the level of NO and the pathological grade and lymph node metastasis of esophageal cancer was discussed. Results: Serum NO levels in patients with esophageal cancer were significantly higher than those in the control group (P < 0.01). In pathological grade, serum NO levels in group II III were significantly higher than those in group I (P <0.01). Serum NO levels were significantly higher than those in the group II (P < 0.05); serum NO levels were not associated with lymph node metastasis. Conclusion : Determination of serum NO content has certain reference value for the diagnosis and prognosis of esophageal cancer