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目的:探讨初发2型糖尿病的治疗效果。方法:对36例新诊断2型糖尿病患者进行为期4周的门冬胰岛素加二甲双胍治疗,先以门冬胰岛素针剂控制血糖2周,然后口服二甲双胍片治疗2周,观察治疗前后的空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、空腹胰岛素(Fins)、C肽(C-P)水平和胰岛素抵抗指数(HomaIR)。结果:患者的FPG、2hPG、HbA1c,胰岛素抵抗指数均较治疗前明显下降(P<0.01),Fins、C肽明显上升(P<0.05)。结论:以门冬胰岛素针剂先控制血糖,然后以二甲双胍片巩固治疗初诊的2型糖尿病患者,能够有效地控制血糖,改善胰岛β细胞功能,且副作用少,值得推广应用。
Objective: To explore the treatment of type 2 diabetes mellitus. Methods: Thirty-six patients with newly diagnosed type 2 diabetes were treated with insulin aspart and metformin for 4 weeks. First, insulin aspart was used to control blood glucose for 2 weeks. Then metformin was taken orally for 2 weeks. Fasting blood glucose (FPG) (2hPG), HbA1c, Fins, C-peptide and HomaIR were measured. Results: The FPG, 2hPG, HbA1c and insulin resistance index of patients were significantly lower than those before treatment (P <0.01), and the levels of Fins and C peptide were significantly increased (P <0.05). CONCLUSION: It is worth to popularize the application of insulin aspart as the first control of blood glucose, and then the treatment of newly diagnosed type 2 diabetes mellitus with metformin tablets can effectively control blood glucose and improve the function of pancreatic β cells with less side effects.