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目的重点综述近5年来Combretastatin A4(CA-4)衍生物的研究进展。方法通过对国内外文献的分析、整理和归纳,较为全面地介绍了具有抗癌活性的微管蛋白聚合抑制剂CA-4衍生物的研究现状。结果与结论具有抗癌活性的天然产物CA-4结构简单,作用机制新颖,以它为先导化合物研究出了许多的类似物,并筛选出一些新药候选物,而且对其衍生物的研究也为此类化合物作用机制研究提供了帮助。
Objective To summarize the research progress of Combretastatin A4 (CA-4) derivatives in recent 5 years. Methods The current research on the anti-cancer activity of CA-4 derivatives, which is a kind of anti-cancer activity, was introduced through analyzing, sorting and summarizing domestic and foreign literatures. RESULTS AND CONCLUSION CA-4, a natural product with anticancer activity, has a simple structure and novel mechanism of action. Many analogues have been developed using it as a lead compound, and some new drug candidates have been screened out and their derivatives have also been studied The mechanism of action of these compounds to help.