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目的 :探讨肝硬化患者发生糖尿病的发病机制及肝硬化与胰岛素抵抗综合征的关系。方法 :观察 17例肝硬化患者与 7例健康自愿者糖耐量试验 ,空腹和服糖后 30 m in、6 0 min、12 0 m in和 180 m in时血糖、胰岛素水平和胰岛素敏感性指数的变化。结果 :肝硬化组与对照组空腹血糖、服糖后 12 0 m in及 180 m in时的血糖无显著性差异 (P>0 .0 5 ) ;服糖后 30 m in、6 0 min时的血糖肝硬化组较对照组高 (P<0 .0 1)。结论 :高胰岛素血症和胰岛素抵抗可能是肝硬化患者发生糖尿病的主要原因。
Objective: To investigate the pathogenesis of diabetic cirrhosis and the relationship between cirrhosis and insulin resistance syndrome. Methods: The changes of blood glucose, insulin and insulin sensitivity index in 17 patients with cirrhosis and 7 healthy volunteers were observed. The fasting blood glucose, insulin and insulin sensitivity index were measured at 30 min, 60 min, 120 min and 180 min . Results: There was no significant difference in fasting blood glucose between the cirrhosis group and the control group after 120 minutes of administration of sugar and blood glucose of 180 minutes (P0.05) Glycemic cirrhosis group than the control group (P <0. 01). Conclusion: Hyperinsulinemia and insulin resistance may be the main causes of diabetes in cirrhotic patients.