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目的探讨肝动脉化疗栓塞(TACE)联合单针道适形射频消融(RFA)治疗大肝癌的特点及疗效。方法对21例TACE治疗效果欠佳的大肝癌患者采用CT引导下经皮RFA治疗。结果 RFA术后4～6周通过MRI或超声造影结合AFP检测综合评价疗效,有效率(71.43%,15/21),疗效满意率(23.81%,5/21)。结论在大肝癌治疗中先行TACE再行RFA的序贯联合治疗具有优势互补的协同作用,单针道适形RFA更具有微创意义。
Objective To investigate the characteristics and therapeutic effects of transcatheter arterial chemoembolization (TACE) combined with single-needle conformal radiofrequency ablation (RFA) in the treatment of large hepatocellular carcinoma. Methods Twenty-one patients with large hepatocellular carcinoma who had poor response to TACE were treated with percutaneous RFA guided by CT. Results The overall efficacy was evaluated by MRI or ultrasound contrast combined with AFP 4 ~ 6 weeks after RFA. The effective rate was 71.43% and 15/21 respectively. The response rate was 23.81% and 5/21 respectively. Conclusions Sequential combined therapy of TACE with RFA in the treatment of large hepatocellular carcinoma has synergetic and complementary synergistic effects. The single-needle conformal RFA is more minimally invasive.