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目的研究丁香苦苷对糖尿病小鼠模型的降糖作用,为临床寻求新的治疗糖尿病药物提供实验基础。方法选用C57BL遗传性肥胖T2DM动物模型(购自齐齐哈尔医学院动物实验中心)db/db小鼠80只(6~8周龄),随机分为模型组,正常对照组,低、中、高丁香苦苷剂量组,模型组和正常对照组采用生理盐水灌胃,剂量组采用12.5,25,50 mg/(kg·d)丁香苦苷灌胃,每天一次,连续4周,每周测量小鼠体质量。结果中、高剂量组体质量均大于模型组和低剂量组(P<0.05);空腹血糖与正常组比较,各模型组与正常组比较,差异均有统计学意义(P<0.05);中、高剂量组与低剂量和模型组相比,组间差异具有统计学意义(P<0.05)。糖耐量中高剂量组与其他组比较差异均有统计学意义(P<0.05);与模型组比较,一小时和两小时,中高剂量糖耐量值显著减少,差异有统计学意义(P<0.05)。结论中、高剂量丁香苦苷对糖尿病小鼠具有一定的降糖作用,为研究丁香苦苷临床疗效提供动物实验基础。
Objective To study the hypoglycemic effects of syringin on diabetic mice and to provide an experimental basis for the clinical search for new drugs for the treatment of diabetes. Methods Eighty (6-8 weeks old) db / db mice of C57BL hereditary obese T2DM animal model (purchased from Animal Experimental Center of Qiqihar Medical College) were randomly divided into model group, normal control group, low, middle and high cloves The doses of simvastatin, the model group and the normal control group were given by intragastric administration of normal saline. The dosage group was administered intraperitoneally with 12.5, 25 and 50 mg / (kg · d) of syringomycin once a day for 4 weeks. Mice Body mass. Results Compared with the normal group, the fasting blood glucose of the model group and the low-dose group were higher than those of the model group and the low-dose group (P <0.05). The differences were statistically significant (P <0.05) The difference between the high dose group and the low dose group was statistically significant (P <0.05). (P <0.05). Compared with the model group, the glucose tolerance at middle and high dose levels significantly decreased at one hour and two hours, with significant difference (P <0.05) . Conclusions Medium and high dose of syringomycin has certain hypoglycemic effect on diabetic mice, providing animal experimental basis for studying the clinical effect of syringin.