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1972年Matuhasi和Hosokawa首先发现在澳大利亚抗原阳性的血清中常可检测到一种能凝集用聚合人血清白蛋白(Polymerized Human SerumAlbumin,pHSA)包被的红细胞的反应物。以后的研究证明该反应物是存在于Dane颗粒和HBsAg上的pHSA受体,并且证明在人肝细胞膜上也存在pHSA受体。现将这方面的研究情况简单综述如下。乙肝病人血清的pHSA结合活性急性乙肝临床起病时血清pHSA结合活性低者,至发病后3～6个月活性全部消失,
In 1972, Matuhasi and Hosokawa first discovered that a reagent capable of agglutinating erythrocytes coated with Polymerized Human Serum Albumin (pHSA) was often found in Australian antigen-positive sera. Subsequent studies have demonstrated that the reactant is a pHSA receptor present on Dane particles and HBsAg and that pHSA receptors are also present on human liver cell membranes. Now the research situation in this area is briefly summarized as follows. Hepatitis B patients with serum pHSA binding activity of clinical onset of acute hepatitis B serum pHSA low binding activity, to 3 to 6 months after the onset of activity all disappear,