论文部分内容阅读
目的 探讨脑卒中与血浆同型半胱氨酸 (Hcy)水平的关系。 方法 采用高效液相色谱分析法和荧光检测法对脑卒中组 10 2例和对照组 80例血浆Hcy水平进行测定 ,并比较高Hcy血症与高血压病、冠心病、高脂血症的关系 ,以及与血浆内VitB12 和叶酸水平的关系。结果 脑卒中组有 5 3例伴Hcy升高 ,占5 1.9% ,平均血浆Hcy浓度 2 0 .6± 8.7μmol/L ,明显高于对照组10 .1± 3.2 μmol/L(P <0 .0 1)。脑卒中患高血压病者 5 7例和患冠心病者 4 9例分别有 35例和 2 8例伴高Hcy血症 ,分别占6 1.4 %和 5 7.1% ,总胆固醇、甘油三脂升高和高密度脂蛋白胆固醇降低伴高Hcy血症者分别为 9例、2 3例和 33例 ,占4 7.4 % (9/ 19)、6 9.7% (2 3/ 33)和 5 7.9(33/ 5 7)。另外 ,脑卒中患者有 2 4例伴叶酸浓度下降 ,其中 2 2例伴高Hcy血症 ,占91.7% ;有 4 2例伴VitB12 浓度减低 ,其中 37例伴高Hcy血症 ,占88.1%。结论 高Hcy血症与脑卒中发病关系十分密切 ,导致高Hcy血症的原因可能是血浆内叶酸和VitB12 的降低。
Objective To investigate the relationship between stroke and plasma homocysteine (Hcy) levels. Methods Plasma homocysteine level was measured in 102 cases of stroke group and 80 cases of control group by HPLC and fluorescence detection. The relationship between hyperhomocysteinemia and hypertension, coronary heart disease and hyperlipidemia was also compared. , And the relationship between plasma VitB12 and folate levels. Results In the stroke group, 53 cases had elevated Hcy, accounting for 5 1.9%. The average plasma Hcy concentration was 20.6 ± 8.7μmol / L, which was significantly higher than that in the control group (10.1 ± 3.2 μmol / L, P <0. 0 1). Fifty-seven patients with stroke and 49 patients with coronary heart disease had hyperlipemia (35%) and 28 patients with hyperhomocysteinemia (61.4% vs 51.1%, respectively). Total cholesterol and triglyceride increased And high density lipoprotein cholesterol with high Hcy hyperlipidemia were 9 cases, 23 cases and 33 cases, accounting for 4 7.4% (9/19), 6 9.7% (23/33) and 5 7.9 (33 / 5 7). In addition, 24 cases of stroke patients with folic acid concentration decreased, of which 22 cases with hyperhomocysteinemia, accounting for 91.7%; 42 cases with decreased concentration of VitB12, 37 cases with hyperhomocysteinemia, accounting for 88.1%. Conclusion Hyperhomocysteinemia is closely related to the pathogenesis of stroke. The cause of hyperhomocysteinemia may be the reduction of plasma folic acid and VitB12.