论文部分内容阅读
目的探讨游离脂肪酸(FFA)、胰岛素抵抗(IR)与新疆哈萨克族代谢综合征(MS)关系。方法在哈萨克族人群现况调查中,随机抽取MS患者195例和健康者120人进行病例对照研究;检测糖代谢相关指标,采用比色法测定FFA浓度,采用放射免疫法测定空腹胰岛素(FINS)浓度,计算胰岛素抵抗指数(HOMA_IR)。结果MS病例组男性FFA为(0.57±0.22)mmol/L,女性为(0.65±0.24)mmol/L,对照组男性为(0.46±0.22)mmol/L,女性为(0.52±0.17)mmol/L;MS病例组男性HOMA_IR为(5.17±4.89),女性为(3.75±3.37),对照组男性为(1.62±1.29),女性为(2.20±1.53);2组男、女性FFA、HOMA-IR差异均有统计学意义(均P<0.01);随着FFA浓度与HOMA_IR的增加,MS患者比例增加;多因素logistic回归分析显示,FFA浓度为0.55 mmol/L～、0.69 mmol/L～,对MS的影响分别OR=4.374(95%CI=1.271～15.046)和OR=4.208(95%CI=1.068～16.586);HOMA_IR为3.96～时,对MS的影响OR=8.552(95%CI=2.064～35.428);FFA、HOMA_IR与MS各组分的相关均有统计学意义(P<0.05);调整年龄、性别、HOMA_IR等影响后,FFA只与腰围、舒张压相关(P<0.05)。结论胰岛素抵抗可能是新疆哈萨克族人群中MS重要的独立危险因素,而FFA可能不是一个独立危险因子,它可能通过其他机制影响机体产生胰岛素抵抗,从而导致MS及其各组分的发生和发展。
Objective To investigate the relationship between free fatty acid (FFA), insulin resistance (IR) and metabolic syndrome (MS) in Xinjiang Kazakh. Methods A total of 195 MS patients and 120 healthy controls were randomly selected from the Kazak population for a case-control study. The indexes related to glucose metabolism were measured and the concentration of FFA was determined by colorimetric assay. The levels of fasting insulin (FINS) Concentration, calculated insulin resistance index (HOMA_IR). Results The male FFA was (0.57 ± 0.22) mmol / L in MS cases and (0.65 ± 0.24) mmol / L in females and (0.46 ± 0.22) mmol / L in males and 0.52 ± 0.17 mmol / L in females (5.17 ± 4.89) in female patients and (3.75 ± 3.37) women in MS group, (1.62 ± 1.29) in male patients and (2.20 ± 1.53) in female patients, respectively (P <0.01). With the increase of FFA concentration and HOMA_IR, the proportion of MS patients increased. The multivariate logistic regression analysis showed that the concentration of FFA was 0.55 mmol / L ~ 0.69 mmol / L ~ (95% CI = 1.271 ~ 15.046) and OR = 4.208 (95% CI = 1.068 ~ 16.586). The effect of HOMA_IR was 3.96 ~, and the effect on MS was 8.552 (95% CI = 2.064 ~ 35.428) ). The correlations of FFA, HOMA_IR and MS were statistically significant (P <0.05). After adjusting for age, sex and HOMA_IR, FFA was only associated with waist circumference and diastolic pressure (P <0.05). Conclusion Insulin resistance may be an important independent risk factor for MS in Xinjiang Kazak population. However, FFA may not be an independent risk factor. It may affect the body’s insulin resistance through other mechanisms, leading to the occurrence and development of MS and its components.