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近年发展起来的共沉淀法是改善难溶性药物的溶解性能和增加体内吸收的新工艺,但国外一般仅用于口服固体制剂。作者用该法将难溶性药物香茶菜甲素及α-细辛醚与水溶性高聚物 PVPK_(30)(聚乙烯吡咯烷酮、平均分子量为40000)制成共沉淀物以增加溶解度配制注射剂,获得较好结果。共沉淀物的制备:将药物和 PVP(载体)按不同比例溶于微量乙醇中,在蒸气浴上除去溶剂,真空干燥备用。本文主要对以上二药与 PVP 按1:2、1:5、1:10、1:20等比例制成的共沉淀物的溶解性能
In recent years, the coprecipitation method developed is to improve the solubility of insoluble drugs and increase the absorption of new technology, but abroad generally only for oral solid preparations. The method used by the method of the insoluble drug Chajinda and α-asarone and water-soluble polymer PVPK_ (30) (polyvinylpyrrolidone, average molecular weight of 40,000) made of coprecipitate to increase the solubility of the injection, Get better results. Preparation of coprecipitate: Dissolve the drug and PVP (carrier) in trace amounts of ethanol in different proportions, remove the solvent in a steam bath, and dry under vacuum for later use. This article mainly on the above two drugs and PVP 1: 2,1: 5,1: 10,1: 20 equal proportion made of coprecipitate solubility