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近年来,人们发现在草分枝杆菌中分离的DNA具有刺激免疫细胞合成细胞因子的能力,这种能力并不依赖于未甲基化Cp G基序的存在,即草分枝杆菌DNA的Cp G甲基化并不影响免疫细胞诱导白细胞介素1 2( IL- 1 2 )的合成。作者合成了一系列源于草分枝杆菌基因组序列的6个碱基长的磷酸二酯
In recent years, it has been found that the DNA isolated from Mycobacterium phlei has the ability to stimulate immune cells to synthesize cytokines, and this ability does not depend on the existence of the unmethylated CpG motif, that is, the Cp of M. gracilis DNA G-methylation did not affect immune cell-induced interleukin-12 (IL-12) synthesis. The authors synthesized a series of 6-base long phosphodiesters derived from the Mycobacterium phlei genome sequence