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目的:研究性激素对十二指肠溃疡(DU)的愈合及对胃酸分泌的影响。方法:用冰醋酸局部涂抹的方法建立大鼠DU模型,第4天起隔日分别注射雌二醇、孕酮、丙酸睾酮,对照组注射生理盐水。术后第23天测定溃疡面积、胃液量和胃酸等。结果:术后72小时各例大鼠都形成了穿通性溃疡,雌雄大鼠溃疡面积无显著差异。术后第23天,雌性对照组、雄性雌二醇组、雄性孕酮组溃疡面积显著小于雄性对照组;雌性对照组、雄性雌二醇组胃液量和胃酸分泌量显著低于雄性对照组。结论:雌二醇和内源性雌激素可通过降低胃酸分泌而加速DU愈合;睾酮对胃酸分泌和DU愈合均无影响;孕酮也加速DU愈合,但对胃酸分泌无影响,推测是通过其它机制起作用的。
Objective: To study the effects of sex hormones on the healing of duodenal ulcer (DU) and its influence on gastric acid secretion. Methods: The model of DU was established by topical application of glacial acetic acid. Estradiol, progesterone and testosterone propionate were injected into the rats on the fourth day, and the control group were injected with normal saline. On the 23rd day after operation, ulcer area, gastric juice volume and gastric acid were measured. Results: Penetrating ulcers were formed in all the rats at 72 hours after operation. There was no significant difference in ulcer area between male and female rats. On the 23rd day after operation, the ulcer area in female control group, male estradiol group and male progesterone group was significantly smaller than that in male control group. The gastric juice volume and gastric acid secretion in female control group and male estradiol group were significantly lower than those in male control group. Conclusion: Estradiol and endogenous estrogen can accelerate DU healing by decreasing gastric acid secretion; testosterone has no effect on gastric acid secretion and DU healing; progesterone also accelerates DU healing but has no effect on gastric acid secretion, presumably through other mechanisms effective.