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本文报道了在[Ca~(2+)]=30mmol/L时,人血清或人血清脂蛋白与各种糖胺聚糖(GAG)及人主动脉两种蛋白聚糖(PG)的相互作用。GAG与血清的作用能力为6—硫酸软骨素(C6—S)>肝素(Hep)>4—硫酸软骨素(C4—S)>透明质酸(HA)>硫酸皮肤素(DS)。极低密度脂蛋白(VLDL)及低密度脂蛋白(LDL)可与肝素作用形成不溶性复合物,而高密度脂蛋白(HDL)则不能。人主动脉硫酸软骨素—PG(CS—PG)、硫酸皮肤素—硫酸软骨素—PG(DS—CS—PG)与血清形成不溶性复合物的曲线类型不同,后者的类型似有利于DS—CS—PG与血清脂蛋白结合从而使之在动脉壁沉积。
This paper reports the interaction of human serum or human serum lipoproteins with various glycosaminoglycans (GAGs) and two human proteoglycans (PGs) at [Ca ~ (2 +)] = 30mmol / L . The ability of GAG to sera was C6-S> Hep> C4-S> Hyaluronic Acid> Dermatan Sulfate (DS). Very low density lipoproteins (VLDL) and low density lipoproteins (LDL) can form insoluble complexes with heparin, whereas high density lipoprotein (HDL) does not. The type of curve that forms insoluble complexes with human serum aorta chondroitin-PG (CS-PG) and dermatan sulfate-chondroitin sulfate-PG (DS-CS-PG) differs from the type of the latter in favor of DS- CS-PG binds to serum lipoproteins to deposit on the arterial wall.