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目的 比较新型寰枢椎侧块融合器与传统内固定方式(TARP+髂骨块内固定技术,后路椎弓根钉棒固定技术)的生物力学差异.方法 收集40例TARP术后病人的CT扫描数据进行测量并设计新型融合器.挑选6具新鲜上颈椎标本.分别进行完整状态,失稳状态及进行3种内固定方式[(TARP+融合器(A1);TARP+髂骨块(A2);后路椎弓根钉棒技术(B)]处理.再测量不同状态下标本的屈伸,侧屈,旋转6组动作的活动范围(ROM)并进行统计学分析.结果 新型融合器有三种型号:13/12/7,12/11/7,11/10/7(长/宽/高);矢状面角设计为:16°/18°/20°.生物力学数据分析显示:Cage组(A1)与髂骨组(A2)在6个方向的活动度差异无统计学差异(P>0.05);在屈伸及旋转活动中,TARP固定组(A1、A2)与后路固定组(B)不存在显著差异(P>0.05);在侧屈活动中,TARP固定组(A1、A2)与后路固定组(B)存在显著差异(P<0.05).结论 配合TARP技术使用的新型融合器与TARP+髂骨块的生物力学稳定性相仿,在侧屈方向优于寰枢椎后路椎弓根螺钉技术.且融合器相对于髂骨块而言,理论上具有以下优势:①简化手术步骤;②避免取髂骨相关并发症.“,”Objective To compare the stabilities of the lateral mass fusion cage and iliac crest autograft combined with Transoral Atlantoaxial Reduction Plate (TARP) system and posterior C1-C2 pedicle screw-rod system. Method Cage was designed based on the three-dimension parameters of 40 postoperative patients operated with TARP. Range of motion (ROM) in flexion-extension, left-right bending and axial rotation of 6 cadaveric specimens with different treatments were recorded. Results The measured data indicated that feasible cage design were in 3 sizes:13/12/7/16°,12/11/7/18°,11/10/7/20°(length/width/height/sagittal angle);ROM of TARP (combined with Cage or ilium) was smaller compared with posterior C1-C2 pedicle screw-rod system and difference between left and right bending was statistically significant. Conclusion The stiffness was analogous between TARP system (combined with cage or iliac crest autograft) and posterior C1-C2 pedicle screw-rod system. Furthermore, cage combined with TARP may simplify surgeric procedure and decrease the incidence of clinical complication.