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肉毒杆菌在生长繁殖时产生的外毒素,是一种大分子旦白质,其结晶体稳定。人类误服肉毒毒素后可引起肉毒中毒。肉毒毒素对周围神经具有特殊的亲和力,主要作用于神经一肌肉连结点,尤其对运动神经及副交感神经有选择牲作用,抑制其神经传导递质(乙酰胆硷)的释放,因而肌肉不收缩,产生软瘫。而软瘫的效应持续时间长,但能完全恢复。又肉毒毒素不能通过血—脑屏障作用于中枢神经系统。A 型肉毒毒素稀释后用以治疗眼部的斜视、睑肌痉挛等,已取得了可喜的进展。本文将有关文献综述如下:
Botulinum toxins in the growth and reproduction produced when it is a macromolecular protein, the crystal stability. Botulinum toxin poisoning can be caused when humans inadvertently poison botulinum toxin. Botulinum toxin has a special affinity for peripheral nerves and acts mainly on the nerve-muscle junction, in particular on the selective action of the motor and parasympathetic nerves, inhibiting the release of the neurotransmitter neurotransmitter (acetylcholine) so that the muscle does not contract , Resulting in soft paralysis. The effect of soft paralysis lasts long, but can be completely restored. Botulinum toxin does not act on the central nervous system through the blood-brain barrier. Botulinum toxin type A diluted for the treatment of strabismus, blepharospasm, etc., has made encouraging progress. This article reviews the literature as follows: