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目的探讨胸腔置管注入尿激酶治疗结核性胸膜炎所致包裹性积液和胸膜肥厚的疗效。方法将96例结核性粘连包裹性胸膜炎患者随机分为置管注药组49例和非注药组47例,注药组注入尿激酶10万U。结果注药组抽液总量(4 281±483)ml,非注药组(959±387)ml(P<0.01);注药组胸膜厚度(1.40±0.20)mm,非注药组(2.5±0.20)mm(P<0.01);注药组胸液消失时间(15±2)d,非注药组(21±3)d(P<0.01)。结论胸腔置管注入尿激酶能显著增加胸液引流量,加快吸收时间,有效降低胸膜肥厚和粘连的发生机会和程度。
Objective To investigate the efficacy of pleural catheter injection of urokinase in the treatment of tuberculous pleurisy caused by encapsulated fluid and pleural thickening. Methods Ninety-six patients with tuberculous adhesive pleuritis were divided randomly into 49 cases of catheter injection group and 47 cases of non-injection group. The injection group was injected with 100000 U of urokinase. Results The total amount of fluid extraction in the injection group was (4 281 ± 483) ml and in the non-infusion group (959 ± 387) ml (P <0.01) ± 0.20) mm (P <0.01). The disappearance time of the pleural effusion in the injection group was (15 ± 2) d and that in the non-infusion group (21 ± 3) d (P <0.01). Conclusion Thoracic catheter infusion of urokinase can significantly increase the drainage of pleural fluid to speed up the absorption time and effectively reduce the incidence and extent of pleural thickening and adhesions.