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目的探讨通心络胶囊对急性心肌梗死患者经皮冠状动脉介入治疗(PCI)术后心肌和微血管的保护作用。方法选取2013年6月—2015年3月在安徽医科大学第二附属医院成功行PCI术的急性心肌梗死患者60例,随机分为对照组和观察组,各30例。对照组患者采用常规药物治疗,观察组患者在常规药物治疗基础上加用通心络胶囊。治疗12个月后比较两组患者心肌功能及微血管功能。结果观察组患者术后左心室射血分数(LVEF)、左心室舒张末期容积(LVEDV)高于对照组(P<0.05);不同时间点比较,差异有统计学意义(P<0.05),二者间存在交互作用,差异有统计学意义(P<0.05)。观察组患者术后室壁节段运动评分指数(WMSI)低于对照组(P<0.05);不同时间点比较,差异有统计学意义(P<0.05),二者间存在交互作用,差异有统计学意义(P<0.05)。静息状态下两组患者血管内径和血流速度比较,差异无统计学意义(P>0.05);充血加压后观察组患者血管直径大于对照组(P<0.05);含服硝酸甘油后观察组患者血管直径大于对照组(P<0.05)。观察组患者术后血清丙二醛(MOA)水平低于对照组,血清一氧化氮(NO)水平高于对照组(P<0.05);不同时间点比较,差异有统计学意义(P<0.05),二者间存在交互作用,差异有统计学意义(P<0.05)。结论通心络胶囊对急性心肌梗死患者PCI术后心肌和微血管具有较好的保护作用,有利于促进患者术后恢复。
Objective To investigate the protective effects of Tongxinluo capsule on myocardium and microvascular after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction. Methods Sixty patients with acute myocardial infarction who underwent PCI successfully in the Second Affiliated Hospital of Anhui Medical University from June 2013 to March 2015 were randomly divided into control group and observation group, with 30 cases in each group. Patients in the control group were treated with conventional drugs. Patients in the observation group were given Tongxinluo capsules on the basis of conventional drug treatment. Twelve months after treatment, myocardial function and microvascular function were compared between the two groups. Results The left ventricular ejection fraction (LVEF) and left ventricular end-diastolic volume (LVEDV) in the observation group were significantly higher than those in the control group (P <0.05). The difference was statistically significant at different time points (P <0.05) There was an interaction between the two groups, the difference was statistically significant (P <0.05). The WMSI in the observation group was lower than that in the control group (P <0.05), and the difference was statistically significant at different time points (P <0.05). There was an interaction between the two groups Statistical significance (P <0.05). There was no significant difference between the two groups in resting blood flow velocity and blood flow velocity (P> 0.05). The blood vessel diameter of the observation group was higher than that of the control group after hyperamalization (P <0.05) The vascular diameter of the patients in the group was larger than that of the control group (P <0.05). The level of serum malonaldehyde (MOA) in the observation group was lower than that in the control group, and the level of serum nitric oxide (NO) was higher in the observation group than in the control group (P <0.05). The difference was statistically significant at different time points ), There is interaction between the two, the difference was statistically significant (P <0.05). Conclusion Tongxinluo Capsule has a good protective effect on myocardium and microvascular after PCI in patients with acute myocardial infarction, which is beneficial to promote postoperative recovery.