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目的：采用随机双盲对照法观察盐酸普鲁卡因栓治疗Ⅰ、Ⅱ期肛裂的临床疗效。方法：分为治疗组（Ａ组３３例）和对照组（Ｂ组３０例），疗程一周。结果：Ⅰ期肛裂疗效；治疗组和对照组痊愈率分别为３８．９％和６．７％；总显效率为７７．８％和２６．７％．总有效率为９４．４％和３３．３％（Ｐ＜０．０１）．Ⅱ期肛裂疗效：治疗组和讨照组痊愈率分别为 ３３．３％和 ０％。总显效率为 ６６．６％和 １３．３％；总有效率为 ９３．３％和 ３３．３％（Ｐ＜ ０．０１）。另外还从肛门疼痛、肛门便血、创面愈合疗效及总疗效上观察到治疗组明显优于对照组（Ｐ＜０．０１）。结论：盐酸普鲁卡因栓治疗 Ⅰ、Ⅱ期肛裂，疗效较好，值得推广应用．
Objective: To observe the clinical efficacy of procaine hydrochloride suppository in the treatment of stage Ⅰ and Ⅱ anal fissure by double-blind randomized controlled trial. Methods: Divided into treatment group (33 cases in group A) and control group (30 cases in group B) for one week. Results: The efficacy of stage Ⅰ anal fissure cure was 38.9% and 6.7% respectively in the treatment group and control group. The total effective rates were 77.8% and 26.7% respectively. The total effective rate was 94.4% and 33.3% (P <0.01). Ⅱ anal fissure effect: the treatment group and the treatment group cure rates were 33.3% and 0%. The total effective rates were 66.6% and 13.3%, respectively. The total effective rates were 93.3% and 33.3% (P <0.01). In addition, it was also observed that the treatment group was superior to the control group (P <0.01) from the anal pain, anal stool, wound healing efficacy and overall efficacy. Conclusion: Procaine Hydrochloride suppository is effective in treating stage Ⅰ and Ⅱ anal fissure, which is worth to be popularized and applied.