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目的观察异甘草酸镁注射液治疗各类慢性肝病的作用。方法选择188例慢性肝病,分为2组治疗。治疗组93例,给予异甘草酸镁注射液100mg加入5%10%GS250ml中,静脉点滴,1次/d,连续4周。对照组95例,给予硫普罗宁注射液200mg加入5%10%GS250ml中,静脉点滴,1次/d,连续4周。治疗结束后进行疗效分析。结果乏力、消化道症状的复常率治疗组分别为91.3%、95.7%;对照组分别为80.6%、77.7%;P均<0.05,差异均有统计学意义。肝区不适复常率治疗组70.6%;对照组65.7%;P>0.05,差异无统计学意义。平均复常天数治疗组分别为15.8d、11.7d、35.2d;对照组分别为21.9d、21.7d、44.5d;P均<0.05,差异均有统计学意义。ALT、AST、TBil明显改善,治疗组复常率分别为95.5%、89.2%、89.2%;对照组分别为80.9%、77.7%、65.2%;P均<0.05,差异均有统计学意义。平均复常天数治疗组分别为17.8d、15.7d、17.8d;对照组分别为27.5d、21.7d、30.2d;P均<0.05,差异均有统计学意义。2组均无明显的不良反应。结论异甘草酸镁能明显改善病毒性、药物性、酒精性等肝脏急性或慢性炎症的临床症状和肝功能指标,并优于硫普罗宁。
Objective To observe the effect of magnesium glycyrrhizinate injection on various chronic liver diseases. Methods 188 cases of chronic liver disease were selected and divided into two groups. In the treatment group, 93 cases were given 100 mg magnesium isoglycyrrhizinate injection into 5% 10% GS 250 ml intravenously once a day for 4 weeks. Control group of 95 cases, given tiopronin injection 200mg added 5% 10% GS250ml, intravenous drip, 1 time / d, for 4 weeks. After the end of treatment efficacy analysis. Results of fatigue, gastrointestinal symptoms normalization rate of the treatment group were 91.3%, 95.7%; control group were 80.6%, 77.7%; P <0.05, the differences were statistically significant. Liver discomfort rate of 70.6% in the treatment group; control group 65.7%; P> 0.05, the difference was not statistically significant. The mean days of recovery from normal treatment were 15.8d, 11.7d and 35.2d, respectively. The control group was 21.9d, 21.7d and 44.5d respectively, all P <0.05, the differences were statistically significant. ALT, AST and TBil were significantly improved in the treatment group, and the rates of recovery were 95.5%, 89.2% and 89.2% respectively in the treatment group and 80.9%, 77.7% and 65.2% in the control group respectively; all P <0.05, the differences were statistically significant. The mean days of recovery from normal treatment were 17.8d, 15.7d and 17.8d respectively, while those in control group were 27.5d, 21.7d and 30.2d, respectively. All the differences were statistically significant. There was no obvious adverse reaction in both groups. CONCLUSION Magnesium isoglycyrrhizinate can significantly improve the clinical symptoms and liver function indexes of acute and chronic liver inflammation, such as viral, medicinal and alcoholic, and is superior to tiopronin.