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目的探讨人乳头状瘤病毒(HPV)在宫颈疾病中的检测及治疗效果。方法采用杂交捕获二代(HC2)技术,检测278例宫颈疾病患者,将HPV-DNA阳性的慢性宫颈炎和宫颈上皮内瘤样病变(CIN)患者随机分成3组分别给予重组人干扰素α-2a栓剂(奥平栓)、聚甲酚磺醛栓剂(爱宝疗)及联合治疗,随诊观察疗效。结果HPV-DNA在CINⅠ、Ⅱ、Ⅲ级、宫颈癌中的阳性表达率分别为70.8%(17/24)、79.3%(23/29)、88.9%(32/36)、91.3%(21/23),均明显高于在慢性宫颈炎中的阳性表达率30.7%(51/166),差异有显著性(P<0.01);且HPV-DNA的阳性表达率随宫颈病变的发展呈逐渐增高的趋势;奥平栓、爱宝疗治疗有效,两者联合治疗效果更佳。结论检测HPV-DNA对宫颈疾病的筛查具有重要意义;奥平栓、爱宝疗联合治疗效果显著。
Objective To investigate the detection and treatment of human papillomavirus (HPV) in cervical diseases. Methods Two hundred and seventy-eight patients with cervical disease were detected by hybridization capture second-generation (HC2) technique. Patients with chronic cervicitis and cervical intraepithelial neoplasia (CIN) who were positive for HPV-DNA were randomly divided into three groups and assigned to receive recombinant human interferon alpha- 2a suppository (Oupin suppository), polycresin sulfonate suppository (Ai Bao therapy) and combined treatment, follow-up observation of efficacy. Results The positive rates of HPV-DNA in CINⅠ, Ⅱ, Ⅲgrade and cervical cancer were 70.8% (17/24), 79.3% (23/29), 88.9% (32/36) and 91.3% 23) were significantly higher than those in chronic cervicitis (30.7%, 51/166), the difference was significant (P <0.01). The positive rate of HPV-DNA was gradually increased with the development of cervical lesions The trend; Aopin suppository, love treasure treatment effective, the two combined treatment effect is better. Conclusion HPV-DNA detection of cervical disease screening is of great significance;