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近年来,世界各国约有150万妇女肌注孕激素类甾体避孕药,炔诺酮庚酸酯是其中之一。本文研究了75例注射炔诺酮庚酸酯妇女的代谢影响。健康妇女75人,肌注炔诺酮庚酸酯,每隔56天注射一次,分别注射12～24次。详细记录用药妇女的身长、体重、饭食和吸烟习惯,并进行了葡萄糖耐量试验,血液学与脂类的分析。对照组妇女年龄和一般情况均与给药组相同,只是不注射炔诺酮庚酸酯,其余研究和给药组相同。注射药物后5～7天,血浆炔诺酮浓度达高峰(10ng/ml)一直持续至25天,以后渐降低。当妇女血浆中药物出现浓度高峰或低浓度时,分别测定了血浆总甘油脂、总胆固醇、低密度酯蛋白—胆固醇和高密度酯蛋白—胆固醇的浓度。结果表明,给药组除了高密度酯蛋白—胆固醇含量显著降低外,其余均无明显差别。葡
In recent years, about 1.5 million women worldwide have been given progestin steroid contraceptives, and norethindrone enoate is one of them. This article studies the metabolic effects of 75 norethindrone in women. 75 healthy women, intramuscular injection of norethindrone acetate, injected once every 56 days, were injected 12 to 24 times. Women’s length, weight, meals and smoking habits were recorded in detail, and glucose tolerance tests, hematology and lipids were analyzed. The age and general condition of women in the control group were the same as those in the administration group, except that norethindrone enoate was not administered, and the rest of the study and the administration group were the same. 5 to 7 days after the injection of the drug, the peak plasma norethindrone concentration (10ng / ml) lasted until 25 days, then gradually decreased. Plasma total glycerol, total cholesterol, low density ester protein-cholesterol, and high-density ester protein-cholesterol concentrations were measured when the concentration of the drug in the plasma was high or low. The results showed that, in addition to the high-density ester protein-cholesterol content decreased significantly, the rest were no significant difference. Portuguese