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孕妇血浆蛋白A(PAPP-A)是新近发现的孕期不断增加的一种大分子糖蛋白。由滋养层,也可能由蜕膜产生(Lin等,1976)。现在已可在早孕(Bischof等,1982)和未孕妇中进行PAPP-A的放射免疫测定。本文作者即用此法测定了252例闭经20～100天的妇女的血浆PAPP-A和hCG(以β-hCG代表),按门诊记录分为未孕组、宫内孕组和宫外孕组(孕龄从末次月经计算),以确定PAPP-A和hCG在宫内与宫外孕病人血浆中水平有无差异,以及滋养层与蜕膜的密切接触是否PAPP-A产生的必要条件。作者发现,宫内孕(153例)闭经71～80天时血浆hCG达到高峰;宫外孕(25例)闭经40天以后hCG明显下降(5±6ng/ml或以下)(P<0.001)。
Pregnant women plasma protein A (PAPP-A) is a newly discovered macromolecule glycoprotein that is continuously increased during pregnancy. By the trophoblast, it may also be produced by the decidua (Lin et al., 1976). PAPP-A radioimmunoassay is now available in early pregnancy (Bischof et al., 1982) and in nonpregnant women. The authors use this method to determine the 252 PAPP-A and hCG (represented by β-hCG) in women with amenorrhea for 20 to 100 days. According to outpatient records, they are divided into non-pregnant group, intrauterine pregnancy group and ectopic pregnancy group Age from the last menstrual period) to determine whether PAPP-A and hCG in patients with intrauterine and ectopic pregnancy plasma levels have no difference, and trophoblast and decidua in close contact whether the necessary conditions for the production of PAPP-A. The authors found that intrauterine pregnancy (153 cases) reached a peak at 71 to 80 days after amenorrhea; hCG was significantly decreased (5 ± 6 ng / ml or less) after elective amenorrhea for 40 days in ectopic pregnancy (P <0.001).