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包公藤(Erucibe obtusfolia Benth)缩瞳有效单体为包公藤甲素。经动物和临床实验证明可作为毛果芸香碱的代用品用于治疗青光眼。包公藤甲素结构尚未阐明,亦无精确的分析方法测定含量,且性质不稳定。为探索其生物利用度测定法,我们对用氯化钠调整渗透压配制的0.025%甲素苯甲酸盐滴眼剂(缩瞳新,pH 6)和用磷酸缓冲液(pH7.0)配制的0.025%甲素苯甲酸盐滴眼剂,用药理指标
Package kudzu (Erucibe obtusfolia Benth) miotic effective monomer is triptolide. Animal and clinical trials have proved that it can be used as a substitute for pilocarpine for the treatment of glaucoma. Triptolide structure has not been elucidated, there is no accurate analytical method for the determination of content, and the nature of instability. To explore its bioavailability assay, we formulated a 0.025% A benzoate eye drop (TMD, pH 6) formulated with sodium chloride to adjust the osmotic pressure and formulated with phosphate buffer (pH 7.0) 0.025% of a benzoin eye drops, with pharmacological indicators