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目的：研究硬膜外腔单次注射吗啡＋布比卡因混合液治疗乳腺癌根治术术后疼痛的可行性。方法：６０例拟行乳腺癌根治术女性患者，分为对照组（Ａ组）２０例和实验组（Ｂ组）４０例。对照组于手术完毕前３０ ｍｉｎ经硬膜外管注入生理盐水１０ｍｌ，实验组注入吗啡２ ｍｇ与 ０．２５％布比卡困混合液１０ ｍｌ。结果：Ｂ组患者的镇痛效果明显优于Ａ组（Ｐ＜０．０５）。Ｂ组副作用如恶心呕吐，瘙痒和尿潴留发生高于Ａ组（Ｐ＜０．０５）。Ａ组ＲＲ术后４，８ｈ下降，与术前相比Ｐ＜０．０５。两组ＭＡＰ，ＨＲ，ＳＰＯ２ 维持正常。结论：高位硬膜外腔注入吗啡与布比卡因混合液用于乳腺癌根治术术后止痛效果确切、安全、经济，但副反应发生率较高。
Objective: To investigate the feasibility of postoperative epidural analgesia after single injection of epidural morphine + bupivacaine for breast cancer patients. Methods: Sixty female patients undergoing radical mastectomy were divided into control group (group A) 20 and experimental group (group B) 40. The control group was injected with 10 ml normal saline through the epidural tube 30 min before the operation was completed. The experimental group was infused with 10 ml morphine 2 mg and 0.25% bupivacaine mixture. Results: The analgesic effect of group B was better than that of group A (P <0.05). B group side effects such as nausea and vomiting, itching and urinary retention occurred higher than the A group (P <0.05). The RR of group A decreased 4 and 8 h after operation, P <0.05 compared with that before operation. Two groups of MAP, HR, SPO2 remained normal. Conclusion: The high epidural injection of morphine and bupivacaine for postoperative radical mastectomy for breast cancer is effective, safe and economical, but the incidence of side effects is high.