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目的 :探讨桥本甲亢 (Hashimotoxicosis,HTC)患者临床甲亢症状持久存在的病因。方法 :应用免疫酶技术 ,检测 2 7例HTC和 33例Graves病 (GD)患者甲状腺组织内甲状腺刺激性免疫球蛋白 (thyroidstimulatingimmunoglobulin ,TSI)的表达情况。结果 :两组病例甲状腺组织内TSI的检出率及表达强度间差异无显著性 (P >0 .0 5 ) ,TSI表达强度与甲亢病情程度无相关性 (P >0 .0 5 )。结论 :HTC甲亢发生和持久存在的主要原因可能与GD相同 ,也是TSI作用的结果。
Objective: To investigate the persistent causes of clinical hyperthyroidism in patients with Hashimotoxicosis (HTC). Methods: Thyroid stimulating immunoglobulin (TSI) expression in thyroid tissue was detected by immunoenzyme in 27 cases of HTC and 33 cases of Graves’ disease (GD). Results: There was no significant difference between the two groups in the detection rate of TSI and the expression intensity (P> 0.05). There was no correlation between the expression of TSI and the severity of hyperthyroidism (P> 0.05). Conclusion: The main reason for the occurrence and persistence of HTC hyperthyroidism may be the same as GD, which is also the result of TSI.