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在肿瘤非特异性免疫治疗中,卡介苗是目前最常用的制剂之一。但是,用活的BGG作为免疫刺激剂还存在不少缺点:(1)BGG最突出的缺点是它是活的传染性病原体。BGG作结核病预防接种后发生播散性病变,世界已报告1,128例以上。在肿瘤免疫治疗时,BGG剂量远超于预防结核的用量,且须多次注射;又因癌症患者由于癌本身或大剂量化疗或放疗后,免疫机能常处于衰竭状态;此时给与BGG,易引起注射局部、区域淋巴结或远处器官的持续性BGG感染,甚至可引起BGG骨髓
In the nonspecific immunotherapy of tumor, BCG is one of the most commonly used preparations. However, there are a number of disadvantages in using live BGG as an immunostimulant: (1) The most prominent drawback of BGG is that it is a live infectious agent. BGG has disseminated lesions after tuberculosis vaccination, and the world has reported more than 1,128 cases. In tumor immunotherapy, BGG dose far exceeds the amount of tuberculosis prevention, and it requires multiple injections; because of cancer patients themselves or after high-dose chemotherapy or radiotherapy, immune function is often in a state of failure; give BGG, Easily cause persistent BGG infections that inject local, regional lymph nodes or distant organs, and may even cause BGG bone marrow