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基础研究领域人物小传:施一公,清华大学生命科学学院院长,中国科学院院士。美国艺术与科学院院士、美国国家科学院外籍院士、欧洲分子生物学组织外籍成员。河南郑州人。提名理由:主要从事细胞凋亡及膜蛋白两个领域的研究。用结构生物学的方法系统研究了哺乳动物、果蝇、线虫三种模式动物的细胞凋亡通路中关键蛋白质及复合物的三维结构,从分子水平上对caspase的激活、抑制、再激活的调控机理进行了诠释。在膜蛋白研究领域,解析了三类膜整合蛋白水解
Basic Biography Biography: Shi Yigong, Dean of School of Life Sciences, Tsinghua University, Chinese Academy of Sciences. American Academy of Arts and Sciences, foreign member of the American Academy of Sciences, and expatriate member of the European Molecular Biology Organization. Zhengzhou, Henan Province. Nomination reasons: mainly engaged in apoptosis and membrane protein in two areas of research. The three-dimensional structure of key proteins and complexes in the apoptotic pathway of mammalian, fruit fly and nematode animal models was systematically investigated by structural biology method, and the regulation of caspase activation, inhibition and reactivation at the molecular level Mechanism for the interpretation. In the field of membrane protein research, three types of membrane-integrated proteolysis are analyzed