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采用双抗体夹心ＥＬＩＳＡ法对３８例正常对照和５２例癫痫患者血清肿瘤坏死因子－α（ＴＮＦ－α）水平进行检测。结果显示癫痫组血清ＴＮＦ－α水平显著高于对照组，血清ＴＮＦ－α水平变化与癫痫患者性别、年龄、病程及发作类型无关，抗癫痫药物对血清ＴＮＦ－α水平无明显影响。提示癫痫患者体内单核－巨噬细胞处于激活状态，ＴＮＦ－α与癫痫发病密切相关
Serum levels of tumor necrosis factor-α (TNF-α) in 38 normal controls and 52 epilepsy patients were detected by double antibody sandwich ELISA. The results showed that serum TNF-αlevels in epilepsy group were significantly higher than those in control group. There was no correlation between serum TNF-αlevel and gender, age, course of disease and type of seizure in epileptic patients. Antiepileptic drugs had no significant effect on serum TNF-αlevel. Prompt monocytes in patients with epilepsy - macrophages in the active state, TNF-α and epilepsy are closely related