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乙型肝炎病毒 (HBV)感染人体后持续存在的机理尚未完全阐明。本文综述了近年来的研究进展 ,从多个方面分析其可能原因。其中包括 :1HBV自身因素 :HBV基因突变、HBe Ag的作用、特殊部位的 HBV感染和感染细胞表面识别分子的改变 ;2机体免疫因素 :选择性免疫抑制、免疫反应抑制病毒基因的表达及对变异株病毒的优先选择生长作用 ;3饮食因素 :乙醇可降低机体对 HBV结构蛋白的细胞免疫应答而利于 HBV持续
The mechanism by which hepatitis B virus (HBV) persists after infection in humans has not yet been fully elucidated. This article summarizes the research progress in recent years and analyzes its possible causes from many aspects. These include: 1HBV self-factors: HBV gene mutation, the role of HBeAg, HBV infection in specific parts of the infected cells and changes in cell surface recognition molecules; 2 immune factors: selective immunosuppression, immune response inhibition of the virus gene expression and mutation Strain virus preferred growth effect; 3 diet factors: ethanol can reduce the body’s cellular immune response to HBV structural protein and conducive to HBV sustained