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氯霉素引起再生障碍性贫血、粒细胞缺乏症已众所周知,但引起急性白血病者,文献上尚不多见。自1955年莱帮和梅塞史密特(Lebon、Messerschmitt)首先报告氯霉素引起急性白血病死亡病例后,才陆续散见于文献。为引起重视,现将我院所见1例报告如下。赵某,男,41岁,百货商店工人。因不规则发热50天,肛腔沉脓10天,于1977年12月10日入院。患者自1974年初至1977年9月,经常腹泻,每次均用氯霉素治疗,在3年零9个月的时间内共服氯霉素150克。于入院前50天开始不规则发热,体温最高达39.3℃。且感肛周疼痛。入院前10天排便时突感肛腔剧痛,随即排出大量脓液,因而入
Chloramphenicol causes aplastic anemia, agranulocytosis has been well known, but caused by acute leukemia, the literature is rare. Since 1955, Le Bang and Messerschmitt first reported cases of death from acute leukemia caused by chloramphenicol, they were scattered in the literature. To attract attention, now see a hospital in our report as follows. Zhao, male, 41 years old, department store worker. Due to irregular fever 50 days, anal pus empyema 10 days, in December 10, 1977 admission. Patients from the beginning of 1974 to September 1977, often diarrhea, each chloramphenicol treatment, in three years and nine months of total cope with chloramphenicol 150 grams. 50 days before admission, irregular fever began, the body temperature up to 39.3 ℃. And feel perianal pain. Ten days before admission defecation suddenly felt anal pain, then discharged a lot of pus, and thus into