C-erbB-2和nm23-H_1产物在结肠癌中表达的意义

• 作 者: 林黎明 秦成坤 张启华 张敏
• 机 构: 山东省立医院普外科
• 出 处: 齐鲁肿瘤杂志
• 发表日期: 1999年02期
• 关键词: 结肠癌组织 C-erbB-2 nm23-H_1 基因产物 淋巴结转移 基因表达 高分化腺癌 特征关系 病理诊断结果 阳性强度

目的：探讨ＣｅｒｂＢ２和ｎｍ２３Ｈ１产物在结肠癌中表达的临床意义。方法：用ＬＳＡＢ法对６４例结肠癌标本的ＣｅｒｂＢ２和ｎｍ２３Ｈ１基因产物的表达进行研究。结果：ＣｅｒｂＢ２蛋白表达与组织类型及淋巴结转移有相关性（Ｐ＜０．０５）；ｎｍ２３Ｈ１表达与淋巴结转移及Ｄｕｋｅｓ分期有相关性（Ｐ＜０．０５）；在结肠癌中两基因产物表达呈正相关（ｒ＝０．４３３Ｐ＜０．０５）。结论：ＣｅｒｂＢ２和ｎｍ２３Ｈ１在结肠癌发生发展中起协同作用，同时检测两种基因产物表达可作为评判结肠癌的临床特征的重要指标。

Objective: To investigate the clinical significance of the expression of CerbB2 and nm23H1 in colon cancer. Methods: The expression of CerbB2 and nm23H1 gene products in 64 specimens of colon cancer was studied by LSAB method. Results: The expression of CerbB2 protein was correlated with histological type and lymph node metastasis (P<0.05). The expression of nm23H1 was correlated with lymph node metastasis and Dukes stage (P<0.05). There was a positive correlation between the expression of the two gene products (r=0.433P<0.05). Conclusion: CerbB2 and nm23H1 play a synergistic role in the occurrence and development of colon cancer. Simultaneously detecting the expression of two gene products can be used as an important index to evaluate the clinical features of colon cancer.