Pharmacokinetics of C-1027 in mice as determined by TCA-RA method

• 作 者: You-PingLiu Quan-ShengLi Yu-Ro
• 机 构: NationalKeyLaboratoryofPharmacokineticsandPharmacodynamics,LaboratoryofDrugMetabolismandPharmacokine
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2005年5期
• 关键词: 药物动力学 C-1027 老鼠 TCA-RA方法 HPLC 三氯乙酸 灵敏性 C-1027 TCA-RA method Pharmacokinetics
• 基金项目: 国家科技攻关项目

AIM: To validate a radioactivity assay, the TCA-RA method,for the measurement of C-1027 in serum and to evaluate its application in determination of pharmacokinetics of C-1027 in mice.METHODS: 125I-C-1027 was prepared by the Iodogen method and separated b