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目的探讨重复经颅磁刺激(rTMS)对后循环短暂性脑缺血发作患者血流速度的影响以及临床疗效观察。方法对132位后循环短暂性脑缺血发作受试者随机分入药物治疗组(分为对照组、阿司匹林组、丁洛地尔+阿司匹林组)和高频rTMS联合药物(丁洛地尔+阿司匹林)治疗组,并用经颅多普勒超声仪(TCD)观察其椎基底动脉脑血流速度在治疗前后的变化。结果患者入高频rTMS+药物治疗组其rT-MS后椎基底动脉,收缩期峰值血流速度(peaksystolicvelocity,Vs)较药物治疗的3组增加明显(P<0.05),舒张末期血流速度(enddiastolicve-locity,Vd)较对照组、阿司匹林组药物治疗组增加(P<0.05)比较丁洛地尔+阿司匹林组差异无统计学意义,平均血流速度(mean velocity,Vm)较药物治疗的3组增加,刺激过程中无明显不适。结论 rTMS能增加后循环缺血患者的脑血流,改善症状,具有临床应用价值。
Objective To investigate the effect of repeated transcranial magnetic stimulation (rTMS) on blood flow velocity in patients with posterior circulation transient ischemic attack and to observe the clinical curative effect. Methods One hundred and thirty-two subjects with transient ischemic attack were randomly divided into two groups: drug-treated group (control group, aspirin group, budesonide plus aspirin group) and high-frequency rTMS combined drug (budesonide + Aspirin) treatment group, and transcranial Doppler ultrasound (TCD) observed vertebrobasilar cerebral blood flow in the changes before and after treatment. Results Compared with the 3 groups, the peak systolic velocity (Vs) of vasospasm of rTMS + drug-treated group was significantly increased (P <0.05) and the end diastolicve (P <0.05). Compared with the control group, aspirin group and drug treatment group had no significant difference (P <0.05), mean velocity (Vm) Increase, no obvious discomfort during stimulation. Conclusion rTMS can increase cerebral blood flow in patients with posterior circulation ischemia and improve symptoms, which has clinical value.