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运用PCR及PCR-SSP技术检测HPV16 DNA和HLA DQB1*03、DRB1*13等位基因在新疆维族、汉族ISCC和对照组织中的分布,探讨HLA DQB1*03,DRB1*13等位基因与HPV16感染和ISCC的相关性及在新疆维族、汉族正常人群中的分布。结果显示:HLA DQB1*03等位基因在维族ISCC和HPV16阳性的ISCC中的分布频率高于维族对照组,差异具有统计学意义(χ2=6.166,P<0.05;χ2=4.336,P<0.05);在维族正常人群中的分布频率低于汉族正常人群,差异具有统计学意义(χ2=14.923,P<0.05)。HLA DRB1*13等位基因在维族、汉族ISCC和HPV16阳性ISCC分布频率与对照组比较,差异均无统计学意义;在维族正常人群中的分布频率与汉族正常人群比较,差异无统计学意义。提示HLA DQB1*03等位基因可能是维族ISCC的遗传易感基因。
To detect the distribution of HPV16 DNA, HLA DQB1 * 03 and DRB1 * 13 alleles in Uygur and Han nationality in Xinjiang Uighur and Han nationality and their control tissues by PCR and PCR-SSP, and to explore the relationship between HLA DQB1 * 03 and DRB1 * 13 alleles and HPV16 infection And ISCC and its distribution in Uygur and Han nationalities in Xinjiang. The results showed that the distribution frequency of HLA DQB1 * 03 allele was significantly higher in Uighur ISCC and HPV16-positive ISCC than in Uighur control (χ2 = 6.166, P <0.05; χ2 = 4.336, P <0.05) ; The distribution frequency in normal Uygur population was lower than that in Han normal population (χ2 = 14.923, P <0.05). The distribution frequency of HLA DRB1 * 13 allele in Uighur, Han ISCC and HPV16 positive ISCC was not significantly different from that in control group. There was no significant difference in the distribution frequency of HLA DRB1 * 13 allele among normal Uighur population and Han normal population. It is suggested that HLA DQB1 * 03 allele may be a genetic predisposition to Uighur ISCC.