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目的研究阿米替林联合多潘立酮对功能性消化不良患者消化症状的改善作用及对TNF-α及IL-4的影响。方法将2015~2016年来我院接受治疗的83例功能性消化不良患者作为研究对象。以数字法随机分成观察组(43例)和对照组(40例)。对照组的患者接受多潘立酮治疗,观察组患者则接受阿米替林联合多潘立酮治疗。治疗后,对两组患者的临床疗效,TNF-α及IL-4的影响进行比较。结果对比两组患者消化症状和肠胃功能的评分发现,治疗前观察组和对照组的评分并未出现明显的差异,但在治疗后两组出现明显差异,且观察组优于对照组,差异均有统计学意义(P<0.05)。观察两种治疗方式对患者TNF-α及IL-4的影响发现,治疗后观察组的TNF-α和IL-4值均优于对照组,差异均有统计学意义(P<0.05)。结论阿米替林联合多潘立酮对功能性消化不良的症状有明显的改善作用,且对患者的TNF-α及IL-4均有积极的影响,该治疗法安全性高,值得临床推广。
Objective To study the amelioration effect of amitriptyline and domperidone on digestive symptoms and the effects of TNF-α and IL-4 in functional dyspepsia patients. Methods A total of 83 patients with functional dyspepsia treated in our hospital from 2015 to 2016 were selected as the study subjects. The patients were randomly divided into observation group (43 cases) and control group (40 cases). Patients in the control group received domperidone, while those in the observation group received amitriptyline plus domperidone. After treatment, the clinical efficacy, the effects of TNF-α and IL-4 in both groups were compared. Results The scores of digestive symptoms and gastrointestinal function in two groups were compared. There was no significant difference between the two groups before treatment, but there was a significant difference between the two groups after treatment, and the observation group was superior to the control group There was statistical significance (P <0.05). To observe the effects of the two treatment methods on TNF-αand IL-4 in patients, the results showed that the levels of TNF-α and IL-4 in the observation group were better than those in the control group after treatment, the differences were statistically significant (P <0.05). Conclusion Amitriptyline combined with domperidone has obvious effect on functional dyspepsia, and has a positive effect on TNF-α and IL-4 in patients. The therapy is safe and worthy of clinical promotion.