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Background Gianotti-Crosti syndrome is characterized by an acute onset of a papular or papulovesicular eruption with a symmetrical distribution.Data sources A PubMed search was conducted using Clinical Queries with the key terms Gianotti-Crosti syndrome ORpapular acrodermatitis.The search strategy included meta-analyses,randomized controlled trials,clinical trials,observa-tional studies,and reviews.This paper is based on,but not limited to,the search results.Results The eruption of Gianotti-Crosti syndrome is found predominantly on the cheeks,extensor surfaces of the extremities,and buttocks.There is a sparing of antecubital and popliteal fossae as well as palms,soles,and mucosal surfaces.Although often asymptomatic,the lesions may be mildly to moderately pruritic.Gianotti-Crosti syndrome is most common in children between 1 and 6 years of age.The Epstein-Barr virus and the hepatitis B virus are the most common pathogens associated with Gianotti-Crosti syndrome.No treatment for Gianotti-Crosti syndrome is necessary because it is self-limited.In an era of vaccine hesitancy and refusal,Gianotti-Crosti syndrome may be important to mention to parents,because it can occur and trigger alarmism.Conclusions Gianotti-Crosti syndrome is mainly a disease of early childhood,characterized by an acute onset of a papular or papulovesicular eruption with a symmetrical distribution.With the advent of more universal vaccination against hepatitis B virus,Epstein-Barr virus has become the most common etiologic agent of Gianotti-Crosti syndrome.Few cases of post-vaccination Gianotti-Crosti syndrome have been reported.Currently,the emphasis should be placed on its self-limiting attribution.