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探讨表皮生长因子受体 (EGFR)和ras原癌基因产物—P2 1蛋白的表达与胃癌生物学行为的关系及其在胃癌发生发展中的作用。方法 :采用免疫组化S -P法。结果 :P2 1ras蛋白在慢性浅表性胃炎、异型增生、胃癌中阳性率分别为 10 % (2 /10 ) ,2 0 % (4 /2 0 ) ,52 .5% (2 1/4 0 ) ,差异有显著性 (P <0 .0 5)。EGFR在正常胃粘膜中均为阴性 ,EGFR在轻、中、重度异型增生的阳性率分别为 3 3 .3 % (3 /9) ,66.7% (4 /6) ,60 % (3 /5)。EGFR在早期和进展期胃癌中的阳性率分别为 2 0 % (2 /10 )和 60 % (18/3 0 ) ,进展期胃癌EGFR的阳性率显著高于早期胃癌 (P <0 .0 5)。结论 :P2 1ras蛋白、EGFR参与了胃癌的发生、发展 ,两者阳性的肿瘤可能具有更强的浸润与转移能力。
To investigate the relationship between the expression of epidermal growth factor receptor (EGFR) and ras proto-oncogene product-P2 1 protein and the biological behavior of gastric cancer and its role in the development of gastric cancer. Methods: Immunohistochemical S-P method was used. Results: The positive rates of P21ras protein in chronic superficial gastritis, dysplasia, and gastric cancer were 10% (2/10), 20% (4/20%), 52.5% (21/4%), respectively. The difference was significant (P < 0.05). EGFR was negative in normal gastric mucosa. The positive rates of EGFR in mild, moderate and severe dysplasia were 3 3% (3/9), 66.7% (4/6), and 60% (3/5) respectively. . The positive rates of EGFR in early and advanced gastric cancer were 20% (2/10) and 60% (18/30) respectively, and the positive rate of EGFR in advanced gastric cancer was significantly higher than that in early gastric cancer (P < 0.05). ). Conclusion : P2 1ras protein and EGFR are involved in the occurrence and development of gastric cancer. Both positive tumors may have stronger ability of invasion and metastasis.