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目的探讨立体定向射频毁损手术对难治性无明确致癎灶癫癎的治疗效果。方法经脑电图、MRI、脑磁图(MEG)检查等术前综合评估无法确定致癎灶的难治性癫癎患者78例,采用立体定向技术进行胼胝体两侧、双侧杏仁核、内侧隔区及单侧Forel-H区等多靶点组合射频毁损治疗,手术后对患者进行跟踪随访、评定疗效。结果按照Engle癫癎疗效分级,本组患者术后1～5年I级+Ⅱ级病例均达82%以上。结论对于临床无明确致癎灶、无法进行开颅致癎灶切除手术的难治性癫癎患者,立体定向手术是一种较好的治疗手段。
Objective To investigate the therapeutic effect of stereotactic radiofrequency ablation on intractable refractory epilepsy. Methods 78 cases of intractable epilepsy caused by foci could not be identified by preoperative comprehensive evaluation such as EEG, MRI and MEG examination. Three sides of the corpus callosum, bilateral amygdala, medial Multiple compartments and unilateral Forel-H area and other multi-target combination of radio frequency rupture therapy, follow-up of patients after surgery to assess the efficacy. Results According to Engle epilepsy efficacy classification, patients in this group 1 to 5 years after I grade + grade Ⅱ cases reached more than 82%. Conclusion Stereotactic surgery is a good treatment for patients with refractory epilepsy who have no definite foci of the stovepipe and can not perform the craniotomy surgery.