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目前一般认为甲氧苄氨嘧啶(Trimethoprim, TMP)和磺胺甲基异恶唑(Sulfamethoxazole,SMZ)合用治疗泌尿系感染比单用SMZ有效,但未经细致的对照试验证实。作者用TMP+SMZ和单用SMZ治疗39例非阻塞性泌尿道感染的患者,其中大多数为复发性膀胱炎的女性患者,以大肠杆菌为主要致病菌。患者随机分组,TMP+SMZ组17例,剂量为TMP80毫克,SMZ 400毫克,每日2次;单用SMZ组22例,剂量为1.0克,每日2次。疗程均为4周,治疗后随访20周以上。结果表明,TMP+SMZ组控制感染比单用SMZ组有效(表1),痊愈率分别为82％和59％,复发
It is generally accepted that the combination of trimethoprim (TMP) and sulfamethoxazole (SMZ) in treating urinary tract infections is more effective than SMZ alone but has not been demonstrated by careful controlled trials. The authors treated 39 patients with non-obstructive urinary tract infections with TMP + SMZ and SMZ alone, most of whom were female patients with recurrent cystitis, with E. coli as the major causative agent. The patients were randomly divided into two groups: TMP + SMZ group (n = 17) at a dose of TMP80 mg and SMZ 400 mg twice a day, and 22 patients in the SMZ group at a dose of 1.0 g twice daily. The course of treatment was 4 weeks, followed up for more than 20 weeks after treatment. The results showed that the control infection in TMP + SMZ group was more effective than SMZ alone (Table 1), the cure rates were 82% and 59%, respectively