论文部分内容阅读
目的考察三七总皂苷iv和ig给药后,人参皂苷Rb1、人参皂苷Rg1和三七皂苷R1在大鼠体内的药物动力学过程,并研究了冰片或维拉帕米的合用对Rb1、Rg1、R1体内过程的影响。方法将Wistar大鼠随机分为两组,分别ig和iv给予三七总皂苷,用HPLC法检测血药浓度,以内标法定量。结果Rb1、Rg1、R1在大鼠体内的药动学过程符合二室模型;与iv给药相比,ig给药后3种成分的相对生物利用度分别仅为2.47%、3.58%、3.25%;与冰片或维拉帕米合用能够影响药物的体内过程。冰片可提高Rb1、Rg1、R1的吸收速率常数,使其Cmax显著增加。维拉帕米则可提高Rb1、Rg1的吸收速率常数并降低其消除速率常数,但对R1的影响不显著。结论三七总皂苷在大鼠体内的过程较复杂,受很多因素的影响。
Objective To investigate the pharmacokinetics of ginsenoside Rb1, ginsenoside Rg1 and notoginsenoside R1 in rats after iv and ig administration, and to study the pharmacokinetics of ginsenoside Rg1 and verapamil to Rb1, Rg1 , R1 in vivo process. Methods Wistar rats were randomly divided into two groups. The total saponins of Panax notoginseng were administered with ig and iv, respectively. The plasma concentrations of pNS were determined by HPLC and quantified by internal standard method. Results The pharmacokinetics of Rb1, Rg1 and R1 in rats were in accordance with the two-compartment model. The relative bioavailability of the three components after iv administration was only 2.47%, 3.58% and 3.25% ; In combination with borneol or verapamil can affect the in vivo process of the drug. Borneol can increase the absorption rate constants of Rb1, Rg1, R1 and increase its Cmax significantly. Verapamil increased the absorption rate constants of Rb1 and Rg1 and decreased their elimination rate constants, but the effect on R1 was insignificant. Conclusion The process of Panax notoginseng in rats is complicated by many factors.