论文部分内容阅读
目的观察乌司他丁对重度烧伤合并吸入性损伤患者的治疗作用。方法符合入组条件的患者共24例,分为对照组和乌司他丁治疗组,乌司他丁治疗组给予每日1次注射用乌司他丁20万单位,持续2周。观察两组治疗前后RR、PaO2、PaCO2、TNF-α、IL-8的浓度变化。结果乌司他丁治疗组与常规治疗组比较,RR、PaO2、IL-8、TNF-α差异均有统计学意义。结论对于重度烧伤合并吸入性损伤的患者,乌司他丁可有效的清除炎性介质,改善患者的呼吸功能。
Objective To observe the curative effect of ulinastatin on patients with severe burn combined with inhalation injury. Methods A total of 24 patients who met the inclusion criteria were divided into control group and ulinastatin group, and ulinastatin group received 200 mg of ulinastatin once daily for 2 weeks. The changes of RR, PaO2, PaCO2, TNF-α, IL-8 levels before and after treatment were observed. Results Compared with the conventional treatment group, the differences of RR, PaO2, IL-8 and TNF-α between the ulinastatin group and the conventional treatment group were statistically significant. Conclusion In patients with severe burn combined with inhalation injury, ulinastatin can effectively remove inflammatory mediators and improve respiratory function.