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目的:回顾性分析D-二聚体(DD)在类风湿性关节炎(RA)中的应用。方法:对129例RA患者、45例风湿性关节炎、51例增生性关节炎、38例结核性关节炎及35例正常对照组DD浓度进行分析,并对129例RA患者DD水平及不同分期进行统计分析,观察各组间关系。结果:RA病人DD水平明显升高,和对照组比较差异有明显统计学意义(P<0.01);不同分期DD浓度比较中中晚期病人DD浓度增高,和早期病人相比差别有统计学意义(P<0.05);并和常见疾病风湿性关节炎、增生性关节炎、结核性关节炎比较差别有明显统计学意义(P<0.01)。结论:RA病人DD浓度明显升高,DD浓度的检测对RA的诊断、分期、鉴别诊断具有一定参考意义。
Objective: To retrospectively analyze the application of D-dimer (DD) in rheumatoid arthritis (RA). Methods: DD concentrations in 129 patients with RA, 45 rheumatoid arthritis, 51 proliferative arthritis, 38 tuberculous arthritis and 35 normal controls were analyzed. DD levels and different stages of 129 RA patients were analyzed. Conduct statistical analysis, observe the relationship between groups. Results: The level of DD in RA patients was significantly higher than that in control group (P <0.01). DD levels in different stages of DD patients were higher than those in early patients (P <0.01) P <0.05). And the common disease rheumatoid arthritis, proliferative arthritis, tuberculous arthritis, the difference was statistically significant (P <0.01). Conclusion: The concentration of DD in patients with RA is significantly higher than that in patients with RA. The detection of DD has some reference value for the diagnosis, staging and differential diagnosis of RA.