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作者用庆大霉素及托勃拉霉素(Tobramycin)治疗了成人及前囱已闭合的儿童的固紫阴性杆菌脑膜炎共7例。全部患者均有败血症。经胃肠外应用各种抗菌素后脊液培养仍然阳性时,开始在鞘内或脑室内注射氨基甙。一般每24小时鞘内或脑室内注射氨基甙5毫克(个别用10毫克),脊液培养阴转后继续用药10天。第1例病人(例1)经鞘内及胃肠外途径应用氨基甙治疗后20、14、12天反复发作。由于出现痛性腰段神经根炎未再继续用氨基甙,其后用氯霉素注射治愈。例2～6经脑室加胃肠外应用氨基甙,感染在第一疗程治愈。6例中只有2例有若干脑积水表现(例2、4)。2例最后经胃肠外及脑室内给药的病人,脊液培养直
The authors used gentamicin and tobramycin to treat 7 cases of solid-violet-negative bacillary meningitis in adults and children with closed anterior flosses. All patients had sepsis. After parenteral use of various antibiotics, culture of spinal fluid is still positive and intrathecal or intracerebroventricular injection of aminoglycosides begins. Generally every 24 hours intrathecal or intracerebroventricular injection of aminoglycoside 5 mg (10 mg each), the culture of the spinal fluid Yin continued after the transfer of 10 days. The first patient (Example 1) recurred 20, 14 and 12 days after intrathecal and parenteral administration of aminoglycoside. Due to the emergence of painful lumbar nerve root inflammation did not continue with aminoglycoside, followed by chloramphenicol injection cure. Cases 2 to 6 intraventricular plus parenteral aminoglycoside infection in the first course of treatment was cured. Only 2 of 6 patients had some hydrocephalus (Examples 2, 4). Two patients were finally treated with parenteral and intraventricular administration, and the spinal cord cultures were straightened